منابع مشابه
Desmosomes from a structural perspective.
Desmosomes are cell-cell junctions responsible for maintaining the structural integrity of tissues by resisting shear forces. Defects result in diseases of mechanically challenged tissues such as skin and heart. The architectural design represents the key to understanding the strength and durability inherent to desmosomes. A number of different proteins contribute to this architecture, and X-ra...
متن کاملStructural studies on desmosomes.
Desmosomes are cadherin-based intercellular junctions that primarily provide mechanical stability to tissues such as epithelia and cardiac muscle. Desmosomal cadherins, which are Ca(2+)-dependent adhesion molecules, are of central importance in mediating direct intercellular interaction. The close association of these proteins, with intracellular components of desmosomes ultimately linked to th...
متن کاملPseudokinases from a structural perspective.
The catalytic (C) subunit of PKA was the first protein kinase structure to be solved, and it continues to serve as the prototype for the protein kinase superfamily. In contrast, by comparing many active and inactive kinases, we developed a novel 'spine' concept where every active kinase is composed of two hydrophobic spines anchored to a hydrophobic F-helix. The R-spine (regulatory spine) is dy...
متن کاملChemokines from a Structural Perspective
Chemokines are a family of small, highly conserved cytokines that mediate various biological processes, including chemotaxis, hematopoiesis, and angiogenesis, and that function by interacting with cell surface G-Protein Coupled Receptors (GPCRs). Because of their significant involvement in various biological functions and pathologies, chemokines and their receptors have been the focus of therap...
متن کاملDesmosomes
What is the electric field used for? Strongly electric fish have an electric organ discharge that is powerful enough to stun prey and to discourage potential predators. The brief, intermittent discharge pulses generated by strongly electric fish can range up to several hundred volts. In contrast, weakly electric fish generate a discharge that is typically less than a single volt. These discharg...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2007
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2007.09.003